Determination of the accumulative toxicity parameters of iron (IV) on white mice

V.B. Dukhnitsky, I.M. Derkach, M.O. Plutenko, I.O. Fritsky, S.S. Derkach

Abstract


Worldwide timely prevention is one of the main tasks in the fight against anemia. Therefore, the development and introduction of new iron preparations does not lose importance in order to provide the pharmaceutical market with anti-anamnetics. One of the promising approaches to the development of such drugs may be the creation of highly stable iron compounds. In this context, one of the promising groups of the compounds of the iron is the so-called clathohelasts, or macrobicyclic complexes.The article presents the parameters of acute toxicity of iron (IV) clathrochelate complexes in laboratory animals. Experimental studies were conducted under the conditions of vivarium and the Department of Pharmacology and Toxicology of the Faculty of Veterinary Medicine of the National University of Life and Environmental Sciences of Ukraine. The indicative experiment was conducted in order to obtain primary information about the range of doses that are close to the average fatal indicator. Then 7 groups of 6 white mice-males in each were formed based on the principle of analogues. Having conducted the indicative experiment in order to obtain primary information about the range of doses that are close to the average fatal indicator, 7 groups of 6 white mice-males in each were formed based on the principle of analogues. Single intravenous solution of iron (IV) clathrochelate complexes was administered to the animals of the experimental groups and they were observed during 14 days. The features of behavior, intake of food and water were noticed, symptoms of intoxication and death of animals were recorded.As a result of the studies, it was found that the average mortality dose of the test substance for internal  administration to white mise  is 1258.3 ± 144.87 mg/kg body weight. According to the classification of chemicals by the degree of danger (GOST 12.1.007-76), of iron (IV) clathrochelate complexescorresponds to the third class of hazard, and according to the classification of substances for toxicity it belong to class IV and as for its toxicity it is  "low toxic substances".


Keywords


iron (IV);clathrochelate complexes;dose;white mice;acute toxicity

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DOI: http://dx.doi.org/10.15421/2018_343

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