Biological role of selenium in the organism of animals and humans

O. Sobolev, B. Gutyj, R. Petryshak, J. Pivtorak, Y. Kovalskyi, A. Naumyuk, O. Petryshak, I. Semchuk, V. Mateusz, A. Shcherbatyy, B. Semeniv


Scientific studies of foreign and domestic scientists convincingly proved, that selenium is a vitally necessary microelement with a wide spectrum of biological action. Despite the small concentrations in the body, selenium has unique multi-functional functions - catalytic, structural, regulatory, - in the process of which he activates the action of many enzymes, vitamins, hormones and thus ensure the normal functioning of various biological systems, the implementation of numerous physiological and biochemical reactions in the living organism. The biochemical functions of selenium are not determined by the trace element itself, but by selenium proteins that contain the selenocysteine residue as an integral part of their active center.  For today more than thirty such specific selenoproteins have been identified and identified in their pure form, the main of which are glutathione peroxidase, thioredoxine reductase, 5-iodothyronine deiodinase, selenoprotein P, and others. Glutathione peroxidases are the main antioxidant enzymes involved in peroxide oxidation of lipids in biological membranes, catalyze the reduction of hydrogen peroxide and almost all organic hydroperoxides, thus protecting the body's cells from reactive oxygen species. Thioredoxin reductase restores the SH-group in a specific thioredoxin protein, which is responsible for maintaining the oxidative-reduction potential in the cell, affects the products of eicosanoids, modulates the processes of inflammation and chemotaxis. Dayon dentiases of the I-III type are responsible for the exchange of thyroid hormones, are involved in the transformation of the "prohormone" of thyroxine into a more active form of influence - triiodothyronine, regulate and maintain a constant concentration of other thyroid hormones. Selenoprotein P is involved in the transport of selenium to various tissues, acts as an agent that helps neutralize toxic effects and remove heavy metals (Pt, Hg), protecting Leydig cells from active forms of oxygen, indirectly affects the synthesis of testosterone and the processes of spermatogenesis. Selenium plays an important role in the functioning of a nonspecific and specific immune system, prevents mutation of viruses and the emergence of new high-pathogenic strains. Selenium inhibits the formation of hyperplastic and enzyme-altered cells caused by aflatoxin B1 or T-2 toxin, capable of destroying molds producing aflatoxins. Selenium is involved in the formation of mechanisms that determine the reproductive function, in particular, stimulates the hormonal function of the fetoplacental complex towards increasing the synthesis of estrogens, activates childbirth and postnatal involutional processes in the organs of the reproductive system, maintains the active function and structural integrity of the sperm, and thereby ensures their high mobility, preservation, and active penetration into the egg cell. The discovery of the biological properties of selenium has become the basis for its use initially in the prophylaxis and treatment of many illnesses and pain symptoms associated with the deficiency of this trace element, and subsequently - in order to increase the productivity of farm animals and poultry, improve the quality of their products and produce dietary food products of a functional purpose, with bio-correcting effect. Despite the considerable amount of conducted research, mechanisms of action of selenium on some metabolic processes in the body are still not fully clarified.



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Ahtjamov, R.R., & Aksjonov, R.I. (2006). Izmenenie massy tushek i organov immuniteta kur pri ispol'zovanii soedinenij selena. Dostizhenija nauki i tehniki APK. 10, 33–34 (in Russian).

Antipov, V.A., Turchenko, A.N., Vasil'ev, V.F., & Kuz'minova, E.V. (2005). Bolezni selenovoj nedostatochnosti u zhivotnyh i ptic: metod. rekomendacii. Moskva (in Russian).

Baraboj, V.A. (2004). Biologicheskie funkcii, metabolizm i mehanizm dejstvija selena. Uspehi sovremennoj biologii. 124(2), 157–168 (in Russian).

Baraboj, V.A., & Shestakova, E.N. (2004). Selen: biologicheskaja rol' i antioksidantnaja aktivnost'. Ukraїns'kij bіohіmіchnij zhurnal. 76(1), 23–31 (in Russian).

Basini, G., & Tamanini, C. (2000). Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide. Domest Anim Endocrinol. 18(1), 1–17. doi: 10.1016/S0739-7240(99)00059-4

Baynes, J.W., & Dominiczak, M.H. (2014). Medical Biochemistry. Elsevier Saunders, Philadelphia.

Bespalov, V.G. (2008). Pitanie i rak. Dieticheskaja profilaktika onkologicheskih zabolevanij. Moskva (in Russian).

Bjorklund, G. (2015). Selenium as an antidote in the treatment of mercury intoxication. Biometals. 28(4), 605–614. doi: 10.1007/s10534-015-9857-5

Bobade, S.P., Sarag, A.N., Rekhate, D.H., Dhok, A.P., Joge, S.V., & Raut, A.E. (2009). Effect of vitamin E and selenium on haemo-immunobiochemical profile of broilers. Indian Journal of Animal Research. 43(1), 169–178.

Bochkarjova, I.I., Bokova, T.I., & Motovilov, K.Ja. (2004). Detoksikacija svinca i kadmija v organizme pticy selenitom natrija. Pishha. Jekologija. Kachestvo: trudy Sibirskogo nauchno-issledovatel'skogo i proektno-tehnologichnogo instituta pererabotki sel'skohozjajstvennoj produkcii, 435–439 (in Russian).).

Bochkarjova, I.I., Bokova, T.I., & Motovilov, K.Ja. (2009). Vzaimodejstvie selensoderzhashhih preparatov i tjazhjolyh metallov v organizme pticy. Sibirskij vestnik sel'skohozjajstvennoj nauki, 1. 50–56 (in Russian).

Bokova, T.I., & Birjukova, S.V. (2007). Ispol'zovanie antioksidantov pri proizvodstve mjasa pticy. Tehnologija i produkty zdorovogo pitanija: sbornik materialov mezhdunarodnoj nauchno-prakticheskoj konferencii, 15–16 (na russkom).

Brigelius-Flohe, R. (1999). Tissue-specific functions of individual glutathione peroxidases. Free Radical Biology and Medicine. 27(9–10), 951–965. doi: 10.1016/S0891-5849(99)00173-2

Brown, S.L., Kolozsvary, A., Liu, J., Jenrow, K.A., Ryu, S., & Kim, J.H. (2010). Antioxidant Diet Supplementation Starting 24 Hours after Exposure Reduces Radiation Lethality. Radiation Research. 173(4): 462–468. doi: 10.1667/RR1716.1

Burk, R.F. (2002).Selenium an antioxidant nutrient.Nutrition in Clinical Care, 5(2), 75–79. doi: 10.1046/j.1523-5408.2002.00006

Burk, R.F., & Hill, K.E. (2009). Selenoprotein P – Expression, Functions, and Roles in Mammals. Biochimica et Biophysica Acta. 1790(11), 1441–1447. doi: 10.1016/J.BBAGEN.2009.03.026

Chena, K., Fanga, J., Penga, X., Cuia, H., Chena, J., Wanga, F.,Chena, Z., Zuoa, Z., Denga, J., Laia, W., & Zhoub, Y. (2014). Effect of selenium supplementation on aflatoxin B1-induced histopathological lesions and apoptosis in bursa of Fabricius in broilers. Food and Chemical Toxicology. 74, 91–97. doi: 10.1016/j.fct.2014.09.003

Cheng, W.H., Valentine, B.A., & Lei, X.G. (1999). High levels of dietary vitamin E do not replace cellular glutathione peroxidase in protecting mice from acute oxidative stress. Nutrition. 129(11), 1951–1957.

Chung, Y.W., Jeong, D., Noh, O.J., Park, Y.H., Kang, S.I., Lee, M.G., Lee, T.H., Yim, M.B., & Kim, I.Y. (2009). Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death. Molecules and Cells. 27(5), 609–613. doi: 10.1007/s10059-009-0074-3

Das, K.C. (2004). Thioredoxin system in premature and newborn biology Antioxidants and Redox Signaling. 6(1), 177–184. doi: 10.1089/152308604771978480

Drachjov, I.S., Legeza, V.I., & Turlakov, Ju.S. (2013). Perspektivy primenenija soedinenij selena v kachestve radioprotektorov. Radiacionnaja biologija. Radiojekologija. 53(5), 475–480 (in Russian). doi:


Drozdova, L.I., & Shackih, E.V. (2009). Sravnitel'naja morfologija immunnyh organov cypljat-brojlerov pri vozdejstvii v rannij postjembrional'nyj period raznymi preparatami selena i joda. Agrarnyj vestnik Urala. 7, 73–75 (in Russian).

El-Sharawy, M., Eid, E., Darwish, S,. Abdel-Razek, I., Islam, M.R., Kubota, K., Yamauchi, N., & El-Shamaa, I. (2017). Effect of organic and inorganic selenium supplementation on semen quality and blood enzymes in buffalo bulls. Animal Science Journal. 88(7), 999–1005. doi: 10.1111/asj.12736

Faixova, Z., Faix, S., Borutova, R., & Leng, Ľ. (2007). Effect of dietary selenium to counteract toxicity of deoxynivalenol growing broiler chickens. Acta Veterinaria Brno. 76, 349–356. doi: 10.2754/avb200776030349

Ferencik, M., & Ebringer, L. (2003). Modulatory effects of selenium and zinc on the immune system. Folia Microbiological. 48(3), 417–426. doi: 10.1007/BF02931378

Fisinin, V.I., Suraj, P.F., & Papazjan, G.T. (2007). Kakaja svjaz' mezhdu selenom i ptich'im grippom. Efektivne ptahіvnictvo. 4, 21–25 (in Russian).

Fordyce, F.M. (2013). Selenium deficiency and toxicity in the environment. Essentials of medical geology, 375–416.

Galachiev, S.M., Dzhioev, F.K., & Sergeev, A.V. (2005). Ispol'zovanie selenita natrija i okisi cinka dlja snizhenija toksikologicheskogo dejstvija svinca. Rossijskij bioterapevticheskij zhurnal. 4(1), 50 (in Russian).

Germain, St. D.L., Galton, V.A., & Hernandez, A. (2009). Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges. Endocrinology. 150(3), 1097–1107. doi: 10.1210/en.2008-1588

Gill, H., & Walker, G. (2008). Selenium, immune function and resistance to viral infections. Nutrition and Dietetics. 65(3), 41–47. doi: 10.1111/j.1747-0080.2008.00260.x

Gogoleva, I.V., & Gromova, O.A. (2009). Selen. Itogi i perspektivy primenenija v pediatrii. Praktika pediatra. 3, 6–9 (in Russian).

Graupner, A., Eide, D.M., Instanes, C., Andersen, J.M., Brede, D.A., Dertinger, S.D., Lind, O.C., Brandt-Kjelsen, A., Bjerke, H., Salbu, B.,Oughton, D., Brunborg, G., & Olsen, A.K. (2016). Gamma radiation at a human relevant low dose rate is genotoxic in mice. Scientific Reports. 6, 32977. doi:10.1038/srep32977

Gromova, O.A. (2007). Nejrotroficheskaja sistema mozga: nejropeptidy, makro- i mikrojelementy, nejrotroficheskie preparaty, Mezhdunarodnyj nevrologicheskij zhurnal, 2, 94–106 (in Russian).

Guberuk, V.O., Gutyj, B.V., & Gufrij, D.F. (2015). Vplyv ursovit-ades ta selenitu natriju na riven' neenzymnoi' systemy antyoksydantnogo zahystu organizmu bychkiv za gostrogo nitratno-nitrytnogo toksykozu. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 17, 1(1), 3–10 (in Ukrainian).

Guberuk, V.O., Gutyj, B.V., & Gufrij, D.F. (2015). Vplyv Ursovit–ADES ta selenitu natriju na aktyvnist' enzymiv glutationovoi' systemy antyoksydantnogo zahystu organizmu bychkiv pry gostromu nitratno–nitrytnomu toksykozi. Visnyk Sums'kogo nacional'nogo agrarnogo universytetu. Serija : Veterynarna medycyna. 1, 151–154 (in Ukrainian).

Guljushin, S. Ju., & Kovaljov, V.O. (2009). Sostojanie sistemy antiradikal'noj zashhity u brojlerov pri primenenii selensoderzhashhih preparatov na fone toksicheskih kormov (obzor). Sel'skohozjajstvennaja biologija. 4, 14–25 (in Russian).

Gunchak, A.V., Ratych, I.B., Anrejeva, L.V., Sirko, Ja.M., & Stojanovs'ka, G.M. (2007). Rol' vitaminu E v zhyvlenni ptyci. Biologija tvaryn. 9(1–2), 70–77 (in Ukrainian).

Gutij, B., 2013. Wpływ dodatków paszowych Meweselu i Metifenu na poziom produktów peroksydacji lipidów w warunkach przewlekłego zatrucia kadmem. Pasze przemysłowe słowe. 4, 24–26.

Gutyj, B., Khariv, I., Binkevych, V., Binkevych, O., Levkivska, N., Levkivskyj, D., & Vavrysevich, Y. (2017). Research on acute and chronic toxity of the experimental drug Аmprolinsyl. Regulatory Mechanisms in Biosystems. 8(1), 41–45. doi: 10.15421/021708

Gutyj, B., Lavryshyn, Y., Binkevych, V., Binkevych, O., Paladischuk, О., Strons'kyj, J., & Hariv I. (2016). Influence of «Metisevit» on the activity of enzyme and nonenzyme link of antioxidant protection under the bull’s body cadmium loading. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj. 18, 2(66), 52–58.


Gutyj, B., Leskiv, K., Shcherbatyy, A., Pritsak, V., Fedorovych, V., Fedorovych, O., Rusyn, V., & Kolomiiets, I. (2017). The influence of Metisevit on biochemical and morphological indicators of blood of piglets under nitrate loading. Regulatory Mechanisms in Biosystems. 8(3), 427–432. doi: 10.15421/021766

Gutyj, B., Martyshchuk, T., Bushueva, I., Semeniv, B., Parchenko, V., Kaplaushenko, A., Magrelo, N., Hirkovyy, A., Musiy, L., & Murska, S. (2017). Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to action of liposomal preparation. Regulatory Mechanisms in Biosystems. 8(2), 304–309. doi:10.15421/021748

Gutyj, B., Nazaruk, N., Levkivska, A., Shcherbatyj, A., Sobolev, A., Vavrysevych, J., Hachak, Y., Bilyk, O., Vishchur, V., & Guta, Z. (2017). The influence of nitrate and cadmium load on protein and nitric metabolism in young cattle. Ukrainian Journal of Ecology. 7(2), 9–13 doi:

Gutyj, B., Paska, M., Levkivska, N., Pelenyo, R., Nazaruk, N., & Guta, Z. (2016). Study of acute and chronic toxicity of ‘injectable mevesel’ investigational drug. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6(2), 174–180. doi:

Gutyj, B., Stybel, V., Darmohray, L., Lavryshyn, Y., Turko, I., Hachak, Y., Shcherbatyy, A., Bushueva, I., Parchenko, V., Kaplaushenko, A., & Krushelnytska, O. (2017). Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load. Ukrainian Journal of Ecology, 7(4), 589–596 doi:

Gutyj, B.V. (2013). Riven' pokaznykiv nefermentnoi' systemy antyoksydantnogo zahystu organizmu bychkiv za umov kadmijevogo navantazhennja. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 15, 1(4), 40–45 (in Ukrainian).

Gutyj, B.V. (2013). Vmist vitaminiv A i E u krovi bychkiv za umov kadmijevoi' intoksykacii'. Visnyk Sums'kogo nacional'nogo agrarnogo universytetu. Serija: Veterynarna medycyna. 2, 31–33 (in Ukrainian).

Gutyj, B.V. (2016). Osobennosti funkcionirovanija sistemy antioksidantnoj zashhity organizma krys pri kadmievom toksikoze. Nauchno-prakticheskij zhurnal. Uchenye Zapiski. Vitebsk. 52(2), 24–28 (in Russian).

Gutyj, B.V., Hufriy, D.F., Hunchak, V.M., Khariv, I.I., Levkivska, N.D., & Huberuk, V.О. (2016). The influence of metisevit and metifen on the intensity of lipid per oxidation in the blood of bulls on nitrate load. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj. 18, 3(70), 67-70 doi:

Gutyj, B.V., Murs'ka, S.D., Gufrij, D.F., Hariv, I.I., Levkivs'ka, N.D., Nazaruk, N.V., Gajdjuk, M.B., Pryjma, O.B., Bilyk, O.Ja., & Guta, Z.A. (2016). Vplyv kadmiievoho navantazhennia na systemu antyoksydantnoho zakhystu orhanizmu buhaitsiv [Influence of cadmium loading on the state of the antioxidant system in the organism of bulls]. Visnyk of Dnipropetrovsk University. Biology, ecology. 24(1), 96–102. doi: 10.15421/011611

Hariv, M.I., & Gutyj, B.V. (2016). Vplyv liposomalnoho preparatu Butaintervit na proteinsyntezuvalnu funktsiiu pechinky shchuriv za otruiennia tetrakhlormetanom [Influence of the liposomal preparation Butaintervite on protein synthesis function in the livers of rats under the influence of carbon tetrachloride poisoning]. Visnyk of Dnipropetrovsk University. Biology, medicine. 7(2), 123–126. doi: 10.15421/021622 (in Ukrainian).

Hariv, M.I., Gutyj, B.V., Vishhur, O.I., & Solovodzins'ka, I.Je. (2016). Funkcional'nyj stan pechinky u shhuriv za umov oksydacijnogo stresu ta dii' liposomal'nogo preparatu. Nauk. zap. Ternop. nac. ped. un-tu. Ser. Biol. 2(66), 76-84 (in Ukrainian).

Hatfield, D.L., & Gladyshev, V.N. (2002). How selenium has altered our understanding of the genetic code. Molecular and Cellular Biology, 22(11), 3565–3576. doi: 10.1128/MCB.22.11.3565-3576.2002

Hatfield, D.L., Schweizer, U., Tsuji, P.A., & Gladyshev, V.N. (2016). Selenium: Its Molecular Biology and Role in Human Health. New York. doi: 10.1007/978-3-319-41283-2

Hill, K.E., Motley, A.K., Stevenson, T.D., Winfrey, V.P., Capecchi, M.R., Atkins, J.F., & Burk, R.F. (2012). Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of biological chemistry. 287(48), 40414–40424. doi: 10.1074/jbc.M112.421404

Holovska, K.Jr, Holovska, K., Boldizarova, K., Čekonová, S., Lenártová, V., Levkut, M., Javorský, P., & Leng, Ľ. (2003). Antioxidant enzyme activities in liver tissue of chickens fid diets supplemented with various forms and amounts of selenium Animal and Feed Sciences. 12(1) 143–152. doi: 10.22358/jafs/67691/2003

Huang, S.A., & Bianco, A.C. (2008). Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nature Reviews Endocrinology. 4(3), 148–155. doi: 10.1038/ncpendmet0727

Huang, Z., Rose, A.H., & Hoffmann, P.R. (2012). The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities. Antioxid Redox Signaling. 16(7), 705–743. doi: 10.1089/ars.2011.4145

Huberuk, V., Gutyj, B., Gufriy, D., Binkevych, V., Hariv, I., Binkevych, O., & Salata, R. (2017). Impact of antioxidants on enzym activities of glutatione system of bulls bodies antioxidant defense under acute nitrate and nitrite toxicity. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj. 19(77), 220–224

Hutyi, B.V., & Hufrii, D.F. (2005). Systema antyoksydantnoho zakhystu ta perekysne okysnennia lipidiv za umov vplyvu seredno toksychnoi dozy nitratu natriiu. Naukovo-tekhnichnyi biuleten instytutu biolohii tvaryn i Derzhavnoho naukovo-doslidnoho kontrolnoho instytutu vetpreparativ ta kormovykh dobavok. 3,4, 116–120. (in Ukrainian).

Imai, H., & Nakagawa, Y. (2003). Biological significance of phospholipid hydroperoxide glutathione peroxidase (PH-GPx, GPx 4) in mamalian cells. Free Radical Biology Medicine. 34(2), 145–169. doi: 10.1016/S0891-5849(02)01197-8

Ivanova, L.V. (2005). Gistologicheskoe stroenie i nekotorye morfometricheskie pokazateli matki samok norki amerikanskoj. Estestvoznanie i gumanizm. 5(2), 75 (in Russian).

Ivchenko, V.K., Ivchenko, D.V., Ivchenko, A.V., Orlova, E.A., Zin'kova, E.V., & Mishherjakova, A.V. (2008). Opredelenie selena v kostnoj tkani cheloveka metodom atomno-absorbcionnoj spektrometrii. Ukraїns'kij zhurnal klіnіchnoї ta laboratornoї medicini. 3(3), 36–38 (in Russian).

Johansson, A.L., Collins, R., Arnér, E.S., Brzezinski, P., & Högb, M. (2012). Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase. PLoS One. 7(1), doi: 10.1371/journal.pone.0030528

Kalinina, E.V. Chernov, N.N., & Saprin, A.N. (2008). Uchastie tio-, peroksi- i glutareduksinov v kletochnyh redoks-zavisimyh processah. Uspehi biologicheskoj himii. 48, 319–358 (in Russian).

Kaur, P., & Bausal, M.P. (2004). Effect of experimental oxidative stress on steroidogenesis and DNA damage in mouse testis. Biomed Science. 11(3), 391–397. doi: 10.1159/000077108

Khan, M.Z., Akter, SH., Islam, M.N., Karim, M.R., Islam, M.R., & Kon, Y. (2007). The effect of selenium and vitamin E on the lymphocytes and immunoglobulin – containing plasma cells in the lymphoid organ and mucosa – associated lymphatic tissues of broiler chickens. Anatomia. Histologia. Embryologia. 37(1), 52–59. doi: 10.1111/j.1439-0264.2007.00799.x

Khariv, M., Gutyj, B., Butsyak, V., & Khariv, I. (2016). Hematolohichni pokaznyky orhanizmu shchuriv za umov oksydatsiinoho stresu ta za dii liposomalnoho preparatu [Hematological indices of rat organisms under conditions of oxidative stress and liposomal preparation action]. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6 (1), 276-289. doi: (in Ukrainian).

Khariv, M., Gutyj, B., Ohorodnyk, N., Vishchur, O., Khariv, I., Solovodzinska, I., Mudrak, D., Grymak, C., & Bodnar, P. (2017). Activity of the T- and B-system of the cell immunity of animals under conditions of oxidation stress and effects of the liposomal drug. Ukrainian Journal of Ecology, 7(4), 536–541. doi:

Khariv, M.I., & Hutyi, B.V. (2017). Dynamika fahotsytarnoi aktyvnosti neitrofiliv u shchuriv za umov oksydatsiinoho stresu ta dii liposomalnoho preparatu. Biolohiia tvaryn. 19(1), 119-124

Kim, Y.J., Chaib, Y.G., & Ryua, J.C. (2005). Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated GSH depletion. Biochemical and Biophysical Research Communications. 330(4), 1095–1102. doi: 10.1016/j.bbrc.2005.03.080

Klicenko, O.A., Sidorkin, V.A., & Ulizko, M.A. (2009). Lechenie i profilaktika selenodeficitnyh sostojanij u s.-h. zhivotnyh i pticy. Efektivne ptahіvnictvo. 1, 44–47 (in Russian).

Kovalenko, M.V., Stepanchenko, L.M., & Shevcova, A.I. (2008). Vplyv selenovmisnyh dobavok na pokaznyky specyfichnogo imunitetu ta nespecyfichnoi' rezystentnosti u kurchat. Fiziologichnyj zhurnal. 54(1), 69–73 (in Ukrainian).

Kovaljov, V. (2006). Ispol'zovanie selensoderzhashhih dobavok dlja profilaktiki hronicheskih toksikozov u cypljat-brojlerov. Nauchno-proizvodstvennyj opyt v pticevodstve : jekspress-informacija, 1, 58–63 (in Russian).

Kravciv, R.J., & Janovich, D.O. (2008). Rol' selena v funkcionirovanii jendokrinnoj sistemy organov i tkanej organizma zhivotnyh. Bіologіja tvarin. 10(1–2), 33–48 (in Russian).

Krynkov, G.V., Castellano, S., Novoselov, S.V., Lobanov, A.V., Zehtab, O., Guigó, R., & Gladyshev, V.N. (2003). Characterization of mammalian selenoproteomes. Science. 300, 1439–1443. doi: 10.1126/science.1083516

Kuczynska, J., & Biziuk, M. (2007). Selenium biochemistry and its monitoring in biological samples. Ecological Chemistry and Engineering. 14, 47–65.

Kudrin, A.V., Skal'nyj, A.V., Zhavoronkov, A.A., Skal'naja, M.G., & Gromova, O.A. (2000). Immunofarmakologija mikrojelementov, Moskva (in Russian).

Kuz'menok, V.A. (2008). Fiziologicheskaja rol' selena v zhivyh organizmah. Agropanorama. 1, 28–30 (in Russian).

Larsen, P.R. (2009). Type 2 Iodothyronine Deiodinase in Human Skeletal Muscle: New Insights into Its Physiological Role and Regulation. Clinical Endocrinology Metabolism. 94(6), 1893–1895. doi: 10.1210/jc.2009-0791

Larsen, P.R., & Zavacki, A.M. (2013). Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action. European Thyroid Journal. 1(4), 232–242. doi: 10.1159/000343922

Lavryshyn, Y. Y., Varkholyak, I. S., Martyschuk, T. V., Guta, Z. А., Ivankiv, L. B., Paladischuk, О. R., Murska, S. D., Gutyj, B. V., & Gufriy, D. F. (2016). The biological significance of the antioxidant defense system of animals body. Scientific Messenger LNUVMBT named after S.Z.

Gzhytskyj. 18, 2(66), 100–111. doi:10.15421/nvlvet6622

Liu, H., Bian, W., Liu, S., & Huang, K. (2012). Selenium protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation by suppressing oxidative stress and ERK signaling pathway. Biological Trace Element Research. 150(1–3), 441–450. doi: 10.1007/s12011-012-9488-4

Lu, J., & Holmgren, A. (2009). Selenoproteins. Biological Chemistry. 284(2), 723–727. doi: 10.1074/jbc.R800045200

Lubos, E., Loscalzo, J., & Handy, D.E. (2011). Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 15(7), 1957–97. doi: 10.1089/ars.2010.3586

Lushchak, V.I. (2012). Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions, Journal of Amino Acids, 26 pages. doi: 10.1155/2012/736837

Lyons, M.P., Papazyan, T.T., & Surai, P.F. (2007). Selenium in Food Chain and Animal Nutrition: Lessons from Nature : review. Asian-Australasian Journal of Animal Sciences. 20(7), 1135–1155.

Lysenko, S.I., & Safonov, V.A. (2006). Vlijanie selensoderzhashhih preparatov na gormonal'no-metabolicheskij gomeostaz i vosproizvoditel'nuju funkciju korov. Iz Selekor. Biologicheskoe dejstvie, 100–103 (in Russian).

Maia, A.L., Goemann, I.M., Meyer, E.L., & Wajner, S.M. (2011). Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease. Endocrinology. 209(3), 287–297. doi: 10.1530/JOE-10-0481

Malinin, O.A., Hmel'nickij, G.A., & Kucan, A.T. (2002). Veterinarnaja toksikologija. Korsun'-Shevchenkovskij (in Russian).

Martyshuk, T. V., Gutyj, B. V., & Vishchur, O. I. (2016). Riven produktiv perekysnoho okysnennia lipidiv u krovi shchuriv za umov oksydatsiinoho stresu ta za dii liposomalnoho preparatu «Butaselmevit» [Level of lipid peroxidation products in the blood of rats under the influence of oxidative stress and under the action of liposomal preparation of ‘‘Butaselmevit’’], Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University. 6 (2), 22–27. doi: (in Ukrainian).

McMullin, P. (2004). A pocket genide to poultry heath and disease. 5 M Enterprises Ltd. Sheffeld.

Medvid, S.M., Hunchak, A.V., Hutyi, B.V., & Ratych, I.B. (2017). Perspektyvy ratsionalnoho zabezpechennia kurchat-broileriv mineralnymy rechovynamy. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 19(79), 127–134 (in Ukrainian).

Men'shikova, E.B., Ljankin, V.Z., Zenkov, I.A., Bondar', I.A., Krugovyh, N.F., & Trufakin, V.A. (2006). Okislitel'nyj stress. Prooksidanty i antioksidanty, Moskva (in Russian).

Mézes, M., & Balogh, K. (2009). Prooxidant mechanisms of selenium toxicity – a review. Acta Biologica Szegediensis, 53(1), 15–18.

Micke, O., Schomburg, L., Buentzel, J., Kisters, K., & Muecke, R. (2009). Selenium in oncology: from chemistry to clinics. Molecules. 14(10), 3975-88. doi: 10.3390/molecules14103975

Moreno-Reyes, R., Egrise, D., Nève, J., Pasteels, J.L., & Schoutens, A. (2001). Selenium deficiency – induced growth retardation is associated, with an impaired bone metabolism and osteopenia. Bone and Mineral Research. 16(8), 1556–1563. doi: 10.1359/jbmr.2001.16.8.1556

Mostert, V. (2000). Selenoprotein P: properties, functions and regulation. Archives of Biochemistry and Biophysics. 376(2), 433–438. doi: 10.1006/abbi.2000.1735

Mubarak, A., Rashid, A., Khan, I., & Hussain, A. (2009). Effect of vitamin E and selenium as immunomodulators on induced aflatoxicosis in broiler birds. Pakistan Journal of Social Science. 7, 31–34.

Murah, V.I., Kolomiec, N.D., Petrova, V.S., Grits, M.A., & Moiseenok, A.G. (2002). Rol' selena v organizme zhivotnogo i cheloveka. Vescі Nacyjanal'naj akadjemіі navuk Belarusі. Seryja : Bіjalagіchnyh navuk. 3, 99–105 (in Russian).

Nalvarte, I., Damdimopoulo, A.E., Rüegg, J., & Spyrou, G. (2015) The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesio. Bioscience Reports, 35(6). doi: 10.1042/BSR20150236

Nayernia, K., Diaconu, M., Aumüller, G., Wennemuth, G., Schwandt, I., Kleene, K., Kuehn, H., & Engel, W. (2004). Pospholipid hydroperoxide glytathione peroxidase: expression pattern during testicular, development in mouse and evolutionary conservation in spermatozoa. Molecular Reproduction and Development. 67(4), 458–464. doi: 10.1002/mrd.20039

Nazaruk, N.V., Gutyj, B.V., & Gufrij, D.F. (2015). Vplyv metifenu ta vitamiksu se na aktyvnist' aminotransferaz syrovatky krovi bychkiv za nitratno–kadmijevogo navantazhennja. Naukovyj visnyk L'vivs'kogo nacional'nogo universytetu veterynarnoi' medycyny ta biotehnologij im. G'zhyc'kogo. 17, 1(1), 121–126 (in Ukrainian).

Nazaruk, N.V., Gutyj, B.V., & Hufrii, D.F. (2012). Vplyv metifenu ta vitamiksu Se na riven produktiv perekysnoho okysnennia lipidiv bychkiv pry khronichnomu nitratno-nitrytnomu toksykozi z kadmiievym navantazhenniam. Naukovyi visnyk LNUVMBT imeni S.Z. Gzhytskoho. 14, 2(52), 265–269 (in Ukrainian).

Nazaruk, N.V., Gutyj, B.V., Murskaja, S.D., Gufrij, D.F., Hariv, I.I., Guta, Z.A., & Vishhur, V.Ja. (2016). Vlijanie vitamiksa Se i metifena na sistemu antioksidantnoj zashhity organizma bychkov pri nitratno-kadmievoj nagruzke. Nauchno-prakticheskij zhurnal. Uchenye Zapiski. Vitebsk. 52(1), 134-138 (in Russian).

Nazyrova, G.V., & Gumarova, G.A. (2010). Vlijanie preparata Sel-pleks na vosproizvoditel'nye kachestva seleznej. Sostojanie, problemy i perspektivy razvitija APK, 183–184 (in Russian).

Nishimura, K., Matsumiya, K., Tsujimura, A., & Okuyama A. (2001). Association of selenoprotein P with testosterone production in cultured Leydig cells. Arch Androe. 47(1), 67–76. doi: 10.1080/01485010152104026

Ognerubova, I.N., & Poddubnaja, I.V. (2009). Primenenie selena v onkologii. Sovremennaja onkologija. 11(2), 56–58 (in Russian).

Papazjan, T.T., Fisinin, V.I., & Suraj, P.F. (2009). Vzaimodejstvie mezhdu vitaminom E i selenom: novyj vzgljad na staruju problemu. Ptica i pticeprodukty. 2, 21–24 (in Russian).

Papazjan, T.T., & Suraj, P.F. (2007). Rol' antioksidantov v razmnozhenii i sposobnosti k oplodotvoreniju pticy. Ptica i pticeprodukty. 2, 49–52 (in Russian).

Pashkovs'ka, N.V. (2015). Selen i zahvorjuvannja shhytopodibnoi' zalozy. Mizhnarodnyj endokrynologichnyj zhurnal, 7(7), 89–93 (in Ukrainian). doi: 10.22141/2224-0721.7.71.2015.72597

Perepelkina, L.I., & Lenchevskij, S.A. (2010). Rol' selena v jekologicheskom obosnovanii vyvedenija tjazhelyh metallov iz organizma zhivotnyh. Dal'nevostochnyj agrarnyj vestnik. 4, 24–27 (in Russian).

Petrosjan, A.B. (2006). Selen: neobhodimyj komponent dlja uluchshenija vosproizvoditel'nyh kachestv petuhov. Ptica i pticeprodukty. 4, 38–41 (in Russian).

Petrovich, Ju.A., Podorozhnaja, R.P., Kichenko, S.M., & Kozlova, M.V. (2004). Issledovanie vlijanija i obmena selensoderzhashhih soedinenij u intaktnyh krys pri perelomah kostej. Bjulleten' jeksperimental'noj biologii i mediciny. 137(1), 85–88 (in Russian).

Philchenkov, A., Zavelevich, M., Khranovskaya, N., & Surai, P. (2007). Comparative analysis of apoptosis induction by selenium compounds in human lymphoblastic leukemia MT-4 cells. Experimental Oncology. 29(4), 257–261.

Pilarczyk, B., Jankowiak, D., Tomza-Marciniak, A., Pilarczyk, R., Sablik, P., Drozd, R., Tylkowska, A., & Skólmowska, M. (2012). Selenium Concentration and Glutathione Peroxidase (GSH-Px) Activity in Serum of Cows at Different Stages of Lactation. Biological Trace Element Research. 147(1–3), 91–96. doi: 10.1007/s12011-011-9271-y

Rassolov, S.N., Eranov, A.M., & Zubova, T.V. (2009). Vlijanie preparata E-selena na vosproizvoditel'nuju funkciju korov. Sibirskij vestnik sel'skohozjajstvennoj nauki. 7, 113–115 (in Russian).

Reilly, C. (2013). Selenium in Food and Health. Springer, Boston. doi: 10.1007/978-0-387-33244-4

Renko, R., Werner, M., Renner-Muller, I., Cooper, T.G., Yeung, C.H., Hollenbach, B., Scharpf, M., Köhrle, J., Schomburg, L., & Schweizer, U. (2008). Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-ircoordination in SePP-knochout mice. Biochemistry. 409(3), 741–749. doi: 10.1042/BJ20071172

Rocha, João B.T., Piccoli, B.C., & Oliveira, C.S. (2017). Oliveirab Biological and chemical interest in selenium: a brief historical account. The Free Internet Journal for Organic Chemistry, 457–491. doi: 10.3998/ark.5550190.p009.784

Rostami, A., Moosavi, S.A., Changizi, V., & Abbasian A.A. (2016). Radioprotective effects of selenium and vitamin-E against 6MV X-rays in human blood lymphocytes by micronucleus assay. Medical journal of the Islamic Republic of Iran. 30, 367.

Saha, U., Fayiga, A., Hancock, D., & Sonon, L. (2016). Selenium in Animal Nutrition: Deficiencies in Soils and Forages, Requirements, Supplementation and Toxicity. International Journal of Applied Agricultural Sciences. 2(6), 112–125. doi: 10.11648/j.ijaas.20160206.15

Schlicht, M., Matysiak, B., Brodreller, B., Wen, X., Liu, H., Zhou, G., Dhir, R., Hessner, M.J., Tonellato, P., Suckow, M., Pollard, M., & Datta, M.W. (2004). Gross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. BMC Genomics’. 5, 58. doi: 10.1186/1471-2164-5-58

Shackih, E.V., Lebedeva, I.A., Makeev, O.G., & Buhancev, V.A. (2008). Parametry sinteza DNK cypljat-brojlerov pod vlijaniem razlichnyh form selena. Agrarnyj vestnik Urala, 6, 49 (in Russian).).

Shackih, E.V., Lebedeva, I.A., Makeev, O.G., & Buharev, V.A. (2007). Genotoksicheskie jeffekty pod vozdejstviem razlichnyh form selena na modeli pticy. Agrarnyj vestnik Urala. 6, 79–80 (in Russian).

Shcherbatyy, A. G., Slivinska, L. G., Gutyj, B. V., Golovakha, V. I., Piddubnyak, A. V., & Fedorovuch, V. L. (2017). The influence of a mineral-vitamin premix on the metabolism of pregnant horses with microelemetosis. Regulatory Mechanisms in Biosystems. 8(2), 293–398. doi:10.15421/021746

Sobolev, M.B. (2004). Osobennosti lechenija toksicheskogo dejstvija tjazhjolyh metallov u detej. Biomedicinskij zhurnal, 5, 191–198 (in Russian).

Sobolev, O.I., Gutyj, B.V., Petryshak, O.J., Golodjuk, I.P., Petryshak, R.A., & Naumjuk, O.S. (2017). Morfologichni ta biohimichni pokaznyky krovi kachenjat, shho vyroshhujut'sja na m’jaso, za riznogo rivnja selenu v kombikormah. Naukovyj visnyk LNUVMBT imeni S.Z. G'zhyc'kogo. 19(74), 57–62 (in Ukrainian).


Sobolev, O.I., & Pacelja, O.A. (2016). Toksychna dija selenu na organizm ptyci. Teoretyczne i praktyczne aspekty rozwoju wspolczesnej nauki, (29.06.2016 – 30.06.2016, Warszawa), 6–8 (in Ukrainian).

Sokyrko, T.O. (2009). Preparaty z antyoksydantnoju dijeju v veterynarnij medycyni – problemy i perspektyvy. Veterynarna biotehnologija: bjuleten'. 14, 212–219 (in Ukrainian).

Steinbrenner, H., Al-Quraishy, S., Dkhil, M.A., Wunderlich, F., & Sies, H. (2015). Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections. Advances in nutrition. 6(1), 73–82. doi: 10.3945/an.114.007575

Suchý, P., Straková, E., Herzig, I. (2014). Selenium in poultry nutrition: a review. Czech Journal of Animal Science, 59(11), 495–503.

Surai, P.F. (2002). Selenium in poultry nutrition: a new look at an old element. 1. Antioxidant properties, deficiency and toxicity. World’s Poultry Science. 58(3), 333–347. doi: 10.1079/WPS20020026

Surai, P.F. (2007). Natural Antioxidants in Poultry Nutrition : new developments. Proceedings of the 16th European Symposium on Poultry Nutrition, 26–30 august, Strasbourg, 669–676.

Surai, P.F., & Taylor-Pickar, J.A. (2008). Current advances in selenium research and applications. Wageningen Academic Publishers. Netherlanls. doi: 10.3920/978-90-8686-642-7

Surai, P.F., & Taylor-Pickard, J.A. (2008). Current advancer in selenium research and applications. Hardback. doi: 10.3920/978-90-8686-642-7

Suraj, P., & Papazjan, T. (2007). Prirodnye antioksidanty v kormlenii pticy: uroki prirody. Ptahіvnictvo: mіzhvіdomchij tematichnij naukovij zbіrnik. 60(2), 76−82 (in Russian).

Tishkov, A.I., & Vojtov, L.I. (1989). Toksikologicheskaja harakteristika selenita natrija. Veterinarija. 11, 65–67 (in Russian).

Tramer, F., Micali, F., Sandri, G., Bertoni, A., Lenzi, A., Gandini, L., & Panfili, E. (2002). Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages. International Journal Andrology. 25(2), 72–83. doi: 10.1046/j.1365-2605.2002.00327.x

Tufarelli, V., & Laudadio, V. (2011). Role and Effect of Selenium and Vitamin E Supplementation in Dairy Ruminant Livestock Production. Vitamin Trace Element, 1, e102. doi: 10.4172/2167-0390.1000e102

Ufer, C., Borchert, A., & Kuhn, H. (2003). Functional characterization of cis and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase. Nucleic Acids Research. 31(15), 4293–4303. doi: 10.1093/nar/gkg650

Ufer, C., & Wang, C.C. (2011). The roles of glutathione peroxidases during embryo development. Frontiers in Molecular Neuroscience. 4, 12. doi: 10.3389/fnmol.2011.00012

Urso, U.R., Dahlke, F., Maiorka, A., Bueno, I.J., Schneider, A.F., Surek, D., & Rocha, C. (2015). Vitamin E and selenium in broiler breeder diets: Effect on live performance, hatching process, and chick quality. Poultry Science. 94(5), 976–983. doi: 10.3382/ps/pev042.

Uysal, H., & Agar, G. (2005). Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster. Brazilian Archives of Biology and Technology. 48(2), 227–233. doi: 10.1590/S1516-89132005000200009

Vanhanen, V.V., Kozjarin, I.P., Ciprijan, V.I., Ivahno, A.P., Ostrovskaja, S.S., & Ponomarenko, V.I. (2003). Radioprotektornoe pitanie: sovremennoe sostojanie problemy. Soobshhenie 2. Ukraїns'kij medichnij chasopis. 1, 53–56 (in Russian).

Vasyl'ceva, L.P., & Paranjak, R.P. (2008). Vplyv selenitu natriju ta askorbatu selenu na biohimichni pokaznyky plazmy krovi gusej za navantazhennja i'h organizmu kadmijem. Naukovo-tehnichnyj bjuleten' Instytutu biologii' tvaryn i Derzhavnogo naukovo-doslidnogo kontrol'nogo instytutu veterynarnyh preparativ ta kormovyh dobavok. 9(4), 18–22 (in Ukrainian).

Voloshin, D.B., Zavodnik, L.B., Pechinskaja, E.S., Shimkus, A. (2008). K mehanizmam antioksidantnogo dejstvija selena. Sel'skoe hozjajstvo – problemy i perspektivy, 2, 34–39 (in Russian).

Wallenberg, M., Misra, S., Wasik, A.M., Marzano, C., Björnstedt, M., Gandin, V., & Fernandesa, A.P. (2014). Selenium induces a multi-targeted cell death process in addition to ROS formation. Journal of Cellular and Molecular Medicine. 18(4), 671–684. doi: 10.1111/jcmm.12214

Weber, M., Balogh, K., Erdelyi, M., & Mezes, M. (2006). Effect of T-2 toxin in combination with vitamin E, selenium and mycotoxin binder on lipid peroxide status and on the glutathione redox system in broiler chicken. Poultry Science. 43(3), 222–227. doi: 10.2141/jpsa.43.222

Zeng, H., Cao, J.J., & Combs, G.F. (2013). Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation. Nutrients. 5(1), 97–110. doi: 10.3390/nu5010097

Zhou, J.C., Zheng, S., Mo, J., Liang, X., Xu, Y., Zhang, H., Gong, C., Liu, X.L., & Lei, X.G. (2017). Dietary Selenium Deficiency or Excess Reduces Sperm Quality and Testicular mRNA Abundance of Nuclear Glutathione Peroxidase 4 in Rats. The Journal of nutrition. 147(10), 1947–1953. doi: 10.3945/jn.117.252544


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